Products and Technology Hyaluronic

Products & Technology

Biodegradable Polymeric Nanoparticles for mRNA Vaccines & Therapeutics

RNA technology is a major achievement in pharmaceutical development and prospective new form of medicine because it leads to the development of therapeutic proteins for treating diseases, ranging from infections diseases to immune diseases, and various RNA drugs have already been approved by US FDA.

mRNA vaccines are not only faster to develop, but they also trigger strong, long-lasting immune responses.

There are major challenges to RNA-based therapeutics, namely that they degrade rapidly and exhibit poor cellular uptake and rapid renal clearance following administration.

We have engineered viral-like vectors comprised of Dextran-spermine nanoparticles for safe, low-immunogenicity, efficient delivery of DNA and RNA therapeutics both in vitro and in vivo, protection from degradation and instability of mRNA at room temperature, and large-scale production capability at low cost. 

Dextran-spermine cationic polysaccharide is prepared by means of reductive-amination between oxidized dextran and natural oligamine seprmine. Polycations used for DNA/RNA delivery are considered to be promising candidates for non-viral delivery technology in part because of their molecular diversity that can be modified for fine-tune their physicochemical properties. 

Cationic polysaccharides are new class of biodegradable polycations capable of complexing and transfecting various genes to many cell lines in relatively high yields and are found to be highly effective in trasnfecting cells in vitro. The in vitro trasnfection efficiencies of the synthetic conjugates are found to be reproducible in term of gene level.

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